Chan Zuckerberg Initiative donations made (filtered to cause areas matching Science)

This is an online portal with information on donations that were announced publicly (or have been shared with permission) that were of interest to Vipul Naik. The git repository with the code for this portal, as well as all the underlying data, is available on GitHub. All payment amounts are in current United States dollars (USD). The repository of donations is being seeded with an initial collation by Issa Rice as well as continued contributions from him (see his commits and the contract work page listing all financially compensated contributions to the site) but all responsibility for errors and inaccuracies belongs to Vipul Naik. Current data is preliminary and has not been completely vetted and normalized; if sharing a link to this site or any page on this site, please include the caveat that the data is preliminary (if you want to share without including caveats, please check with Vipul Naik). We expect to have completed the first round of development by the end of March 2022. See the about page for more details. Also of interest: pageview data on analytics.vipulnaik.com, tutorial in README, request for feedback to EA Forum.

Table of contents

Basic donor information

ItemValue
Country United States
Wikipedia pagehttps://en.wikipedia.org/wiki/Chan_Zuckerberg_Initiative
Facebook username chanzuckerberginitiative
Websitehttps://www.chanzuckerberg.com/
Page on philosophy informing donationshttps://www.chanzuckerberg.com/about
Data entry method on Donations List WebsiteManual (no scripts used)

Donor donation statistics

Cause areaCountMedianMeanMinimum10th percentile 20th percentile 30th percentile 40th percentile 50th percentile 60th percentile 70th percentile 80th percentile 90th percentile Maximum
Overall 123 220,215 593,029 43,192 85,000 117,437 155,000 199,994 220,215 249,691 250,000 1,050,000 2,500,000 2,500,000
Science 123 220,215 593,029 43,192 85,000 117,437 155,000 199,994 220,215 249,691 250,000 1,050,000 2,500,000 2,500,000

Donation amounts by cause area and year

If you hover over a cell for a given cause area and year, you will get a tooltip with the number of donees and the number of donations.

Note: Cause area classification used here may not match that used by donor for all cases.

Cause area Number of donations Number of donees Total 2019 2018
Science (filter this donor) 123 72 72,942,623.00 5,000,000.00 67,942,623.00
Total 123 72 72,942,623.00 5,000,000.00 67,942,623.00

Graph of spending by cause area and year (incremental, not cumulative)

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Graph of spending by cause area and year (cumulative)

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Donation amounts by subcause area and year

If you hover over a cell for a given subcause area and year, you will get a tooltip with the number of donees and the number of donations.

For the meaning of “classified” and “unclassified”, see the page clarifying this.

Subcause area Number of donations Number of donees Total 2019 2018
Science 123 72 72,942,623.00 5,000,000.00 67,942,623.00
Classified total 123 72 72,942,623.00 5,000,000.00 67,942,623.00
Unclassified total 0 0 0.00 0.00 0.00
Total 123 72 72,942,623.00 5,000,000.00 67,942,623.00

Graph of spending by subcause area and year (incremental, not cumulative)

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Graph of spending by subcause area and year (cumulative)

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Donation amounts by donee and year

Donee Cause area Metadata Total 2019 2018
University of California, San Francisco (filter this donor) 7,304,008.00 0.00 7,304,008.00
California Institute of Technology (filter this donor) FB Tw WP Site 5,215,530.00 0.00 5,215,530.00
Regents University of California Los Angeles (University of California, Los Angeles) (filter this donor) 5,000,000.00 2,500,000.00 2,500,000.00
Cold Spring Harbor Laboratory (filter this donor) 4,484,012.00 0.00 4,484,012.00
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford University) (filter this donor) 2,908,376.00 2,500,000.00 408,376.00
Harvard Medical School (filter this donor) 2,849,730.00 0.00 2,849,730.00
The University of Texas at Austin (filter this donor) 2,745,849.00 0.00 2,745,849.00
University of Cambridge (filter this donor) FB Tw WP Site 2,545,000.00 0.00 2,545,000.00
Vanderbilt University (filter this donor) FB Tw WP Site 2,500,000.00 0.00 2,500,000.00
University of Florida (filter this donor) FB Tw WP Site 2,500,000.00 0.00 2,500,000.00
Mount Sinai Medical Center Inc (filter this donor) 2,500,000.00 0.00 2,500,000.00
University of Utah School of Medicine (filter this donor) 2,500,000.00 0.00 2,500,000.00
The Salk Institute For Biological Studies (filter this donor) 2,500,000.00 0.00 2,500,000.00
President and Fellows of Harvard College (Harvard Medical School) (filter this donor) 2,500,000.00 0.00 2,500,000.00
Broad Institute of MIT and Harvard (filter this donor) 1,556,030.00 0.00 1,556,030.00
The Regents of the University, Santa Cruz (University of California, Santa Cruz) (filter this donor) 1,400,000.00 0.00 1,400,000.00
Regents of the University of California at San Diego (University of California, San Diego) (filter this donor) 1,309,945.00 0.00 1,309,945.00
Washington University in St Louis (filter this donor) 1,200,119.00 0.00 1,200,119.00
The Trustees of Columbia University in the City of New York (Columbia University) (filter this donor) 1,160,000.00 0.00 1,160,000.00
VIB-KULeuven (filter this donor) 1,050,000.00 0.00 1,050,000.00
Duke University (filter this donor) FB Tw WP Site 1,050,000.00 0.00 1,050,000.00
University of Texas Southwestern Medical Center (filter this donor) 1,050,000.00 0.00 1,050,000.00
Karolinska Institutet (filter this donor) FB Tw WP Site 1,050,000.00 0.00 1,050,000.00
Wyss Institute at Harvard University (filter this donor) 1,050,000.00 0.00 1,050,000.00
Regents of the University of Michigan (University of Michigan) (filter this donor) 800,063.00 0.00 800,063.00
Dana-Farber Cancer Institute (filter this donor) WP 791,341.00 0.00 791,341.00
The Board of Regents of the University of Wisconsin System (University of Wisconsin) (filter this donor) 770,729.00 0.00 770,729.00
European Molecular Biology Laboratory (filter this donor) FB Tw WP Site 743,478.00 0.00 743,478.00
School of Medicine - Johns Hopkins University (Johns Hopkins University) (filter this donor) 675,892.00 0.00 675,892.00
ZappyLab (Protocols.io) (filter this donor) 600,000.00 0.00 600,000.00
Princeton University (filter this donor) FB Tw WP Site 549,807.00 0.00 549,807.00
The General Hospital Corporation dba Massachusetts General Hospital (Massachusetts General Hospital) (filter this donor) 499,906.00 0.00 499,906.00
Wellcome Sanger Institute (filter this donor) 479,497.00 0.00 479,497.00
Monash University (filter this donor) FB Tw WP Site 423,449.00 0.00 423,449.00
The Board of Trustees of the University of Illinois (University of Illinois) (filter this donor) 420,000.00 0.00 420,000.00
American Association for the Advancement of Science (American Association for the Advancement of Science) (filter this donor) 347,129.00 0.00 347,129.00
The Trustees of the University of Pennsylvania (University of Pennsylvania) (filter this donor) 270,491.00 0.00 270,491.00
Massachusetts General Hospital (filter this donor) WP Site 250,000.00 0.00 250,000.00
Lawrence Berkeley National Lab (filter this donor) 250,000.00 0.00 250,000.00
The Jackson Laboratory (filter this donor) 250,000.00 0.00 250,000.00
J. Craig Venter Institute (filter this donor) Tw WP Site 249,739.00 0.00 249,739.00
Fundació Centre de Regulació Genòmica (CRG-CNAG) (filter this donor) 249,411.00 0.00 249,411.00
École Polytechnique Fédérale de Lausanne (EPFL) (filter this donor) 240,350.00 0.00 240,350.00
University of Dundee (filter this donor) WP Site 227,200.00 0.00 227,200.00
University of Zurich (filter this donor) FB Tw WP Site 225,081.00 0.00 225,081.00
College of Physicians and Surgeons of Columbia University (Columbia University) (filter this donor) 220,462.00 0.00 220,462.00
Massachusetts Institute of Technology (MIT) (filter this donor) 220,215.00 0.00 220,215.00
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford Univeristy) (filter this donor) 212,750.00 0.00 212,750.00
University of Chicago (filter this donor) FB Tw WP Site 207,328.00 0.00 207,328.00
Yale University, School of Medicine (filter this donor) 200,472.00 0.00 200,472.00
Regents of the University of California at Berkeley (University of California, Berkeley) (filter this donor) 200,000.00 0.00 200,000.00
Icahn School of Medicine at Mount Sinai/Continuum Health Partners Inc (Icahn School of Medicine at Mount Sinai) (filter this donor) 199,994.00 0.00 199,994.00
Helmholtz Zentrum München, German Research Center for Evironmental Health (filter this donor) 175,295.00 0.00 175,295.00
Aalto University Foundation (filter this donor) 170,296.00 0.00 170,296.00
Weizmann Institute of Science (filter this donor) 160,029.00 0.00 160,029.00
New York Genome Center (filter this donor) 157,402.00 0.00 157,402.00
ASAPbio (filter this donor) 150,000.00 0.00 150,000.00
The Research Foundation for SUNY (filter this donor) 132,703.00 0.00 132,703.00
University College London (filter this donor) FB Tw WP Site 126,097.00 0.00 126,097.00
The University of Texas MD Anderson Cancer Center (filter this donor) 125,111.00 0.00 125,111.00
Georgia Institute of Technology (filter this donor) FB Tw WP Site 124,510.00 0.00 124,510.00
The Walter and Eliza Hall Institute of Medical Research (filter this donor) 117,437.00 0.00 117,437.00
University of Edinburgh (filter this donor) 116,534.00 0.00 116,534.00
The University of Melbourne (filter this donor) 105,825.00 0.00 105,825.00
University of Eastern Finland (filter this donor) 100,917.00 0.00 100,917.00
The Regents of University of California, Davis campus (University of California, Davis) (filter this donor) 99,084.00 0.00 99,084.00
Heriot-Watt University (filter this donor) 88,000.00 0.00 88,000.00
Roswell Park Alliance Foundation (filter this donor) 85,000.00 0.00 85,000.00
Stony Brook Foundation (Stony Brook University) (filter this donor) 70,000.00 0.00 70,000.00
Fred Hutchinson Cancer Research Center (filter this donor) FB Tw WP Site 45,000.00 0.00 45,000.00
Cornell University (filter this donor) FB Tw WP Site 45,000.00 0.00 45,000.00
Brigham and Women's Hospital, Inc. (filter this donor) 45,000.00 0.00 45,000.00
Total -- -- 72,942,623.00 5,000,000.00 67,942,623.00

Graph of spending by donee and year (incremental, not cumulative)

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Graph of spending by donee and year (cumulative)

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Donation amounts by influencer and year

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Donation amounts by disclosures and year

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Donation amounts by country and year

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Full list of donations in reverse chronological order (123 donations)

Graph of top 10 donees by amount, showing the timeframe of donations

Graph of donations and their timeframes
DoneeAmount (current USD)Amount rank (out of 123)Donation dateCause areaURLInfluencerNotes
Regents University of California Los Angeles (University of California, Los Angeles)2,500,000.0012019Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2019–2024. This grant supports providing mechanistic frameworks for the study of neurodegenerative tauopathies by generating unbiased, comprehensive, and validated single-cell data from clinically relevant human brain tissue. (PI: Inma Cobos, Early Career Award).
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford University)2,500,000.0012019Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2019–2024. This grant supports developing novel human cellular models of brain function and maturation to enable mechanistic studies of neurodegeneration. (PI: Sergiu Pasca, Early Career Award).
The University of Texas at Austin245,849.00572018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the design of frameworks and systems which close the gap between computer vision algorithm and human performance for analyzing live cells observed in videos. (PI: Danna Gurari, Human Cell Atlas Computational Tools RFA).
The University of Texas at Austin2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports leveraging systems immunology tools to profile single T-cells that infiltrate into the brain during neurodegeneration. These experiments will be informative for understanding the role of the immune system in neurodegeneration and for developing immune-based detection and treatment approaches. (PI: Ning Jiang, Early Career Award).
The University of Texas MD Anderson Cancer Center125,111.00952018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of novel methods and tools for joint identification of cell-types from multimodal single-cell datasets. (PI: Ken Chen, Human Cell Atlas Computational Tools RFA).
The Walter and Eliza Hall Institute of Medical Research117,437.00992018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the creation of a benchmark data set and analysis platform that allows for an unbiased comparison of single-cell RNA-sequencing analysis methods. (PI:Matthew Ritchie, Human Cell Atlas Computational Tools RFA).
Fred Hutchinson Cancer Research Center45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI: Raphael Gottardo, Human Cell Atlas Computational Tools RFA).
Fundació Centre de Regulació Genòmica (CRG-CNAG)249,411.00512018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the systematic benchmarking of single-cell RNA sequencing methods to identify techniques suitable for the production of a Human Cell Atlas. (PI: Holger Heyn, Human Cell Atlas Computational Tools RFA).
University College London126,097.00942018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development and support a suite of probabilistic analysis methods for analysis of single-cell and in situ RNA-seq data. (PI: Kenneth Harris, Human Cell Atlas Computational Tools RFA).
University of California, San Francisco575,000.00312018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of methods for permanently recording cell state changes in DNA in a compact manner that can be read out in single cell format using droplet-based single cell RNA-seq. (PI: Jonathan Weissman).
University of California, San Francisco179,317.00772018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development and incorporation of machine learning algorithms for segmentation of cellular organelles into the soft x-ray tomography pipeline and generate images of segmented cells for the Human Cell Atlas. (PI: Carolyn Larabell, Human Cell Atlas Computational Tools RFA).
Georgia Institute of Technology124,510.00972018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of algorithms to jointly consider imputation and clustering analysis for single-cell RNA sequencing data which are zero-inflated. (PI: Peng Qiu, Human Cell Atlas Computational Tools RFA).
University of California, San Francisco250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the use multiplexed single cell RNA-sequencing to construct a provisional version of the Human Immune Census across three ethnicities and to develop a new suite of computational tools to analyze the resulting data. (PI: Jimmie Ye, Human Cell Atlas Computational Tools RFA).
University of California, San Francisco249,691.00502018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the building and contribution to a set of tools to address the analysis of single cell RNAseq data using the popular Cytoscape network analysis ecosystem. (PI: John Morris, Human Cell Atlas Computational Tools RFA).
University of California, San Francisco2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports using machine learning and systems pharmacology methods to characterize novel bioactive small molecules able to control cellular processes underlying proteinopathies. (PI: Michael Keiser, Early Career Award).
University of California, San Francisco2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports leveraging a CRISPR-based functional genomics platform in human iPSC-derived neurons and glia to elucidate cellular mechanisms of neurodegenerative diseases. (PI: Martin Kampmann, Early Career Award).
University of California, San Francisco1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports bridging the pathophysiological knowledge gap between human genetic risk pathways and neuropathological findings through deep, systematic phenotyping of a set of human fibroblast, induced neuron, and post-mortem tissue resources all derived from the same individual patients. (PI: William Seeley, Collaborative Science Award).
University of Cambridge45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI:John Marioni, Human Cell Atlas Computational Tools RFA).
University of Cambridge2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grants supports the identification of the mechanisms by which metabolic factors contribute to neurodegeneration, and to harness these insights to slow disease progression. (PI: Florian T. Merkle, Early Career Award).
Harvard Medical School150,000.00892018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development and application of computational tools that utilize somatic mutations at microsatellites as genetic barcodes to reconstruct cell lineage patterns from single-cell sequencing data. (PI: Peter Park, Human Cell Atlas Computational Tools RFA).
University of Chicago207,328.00672018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the generation of an open, reproducible, and extensible benchmark platform for evaluating computational tools for single cell differential expression analysis. (PI: Matthew Stephens, Human Cell Atlas Computational Tools RFA).
Harvard Medical School199,730.00752018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a tool, called SPRING, allowing users to interactively explore topology and gene expression features in high-dimensional single cell data, using force-directed graph layouts. (PI: Allon Klein, Human Cell Atlas Computational Tools RFA).
University of Dundee227,200.00592018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the creation of the Human Cell Atlas Image Data Resource (HCA-IDR) and new software analytics capabilities by integrating existing tools into the Human Cell Atlas Data Coordination Platform for image ingestion, storage, and metadata association and by developing the *fish (Star-fish) project for generalized image analysis capabilities. (PI: Jason Swedlow, Human Cell Atlas Computational Tools RFA).
Harvard Medical School2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the development of computational discovery tools for large-scale structure determination of macromolecules, of conformational changes and for quantitative prediction of effects human genetic variants in neurodegenerative disease. (PI: Debora Marks, Early Career Awards).
University of Eastern Finland100,917.001072018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of deep neural network (autoencoder) models for single cell data and testing their application to generate a suitable data representation for downstream analysis of cell phenotypes, such as metabolic activity prediction. (PI:Merja Heinäniemi, Human Cell Atlas Computational Tools RFA).
University of Edinburgh116,534.001002018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of software for an atlas framework enabling image integration, annotation and analysis, including tools for the clinical domain expert with sharing of image data and comparative analysis of normal and diseased tissues across species. (PI: Mark Arends, Human Cell Atlas Computational Tools RFA).
University of Florida2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the study of disrupted transport of proteins and RNA and accelerated repeat expansion to better model neurodegenerative processes. (PI: Eric Wang, Early Career Award).
University of Texas Southwestern Medical Center1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports development of structural metrics that define neurodegenerative tauopathies with the long term goal of developing a simple diagnostic test that will identify those in an asymptomatic population who are at risk of developing disease. (PI: Marc Diamond, Collaborative Science Award).
Helmholtz Zentrum München, German Research Center for Evironmental Health175,295.00792018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the building of an interactive, distributed environment for analyzing single cell RNA seq data topology (trajectories, clusters) and associated driving genes. (PI: Fabian Theis, Human Cell Atlas Computational Tools RFA).
University of Utah School of Medicine2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the investigation of mechanisms of viral-like intercellular communication in the brain that mediate initial etiology of Alzheimer's Disease. (PI: Jason Shepherd, Early Career Award).
Heriot-Watt University88,000.001102018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of software for an atlas framework enabling image integration, annotation and analysis, including tools for the clinical domain expert with sharing of image data and comparative analysis of normal and diseased tissues across species. (PI: Albert Burger, Human Cell Atlas Computational Tools RFA).
University of Zurich225,081.00602018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of benchmarks and flexible statistical methods and software tools for discovery in high throughput single cell datasets. (PI: Mark Robinson, Human Cell Atlas Computational Tools RFA).
Vanderbilt University2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grants supports exploring regulatory networks that govern transporter expression and activity in the blood-brain barrier, and to leverage this understanding towards rational therapeutic interventions in neurodegeneration. (PI: Ethan Lippmann, Early Career Award).
VIB-KULeuven1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports the development of a multi-well CMOS chip that allows us to print defined induced human microcircuits of Parkinson's patients cells, enabling us to test the role of pathogenic pathways (synaptic autophagy, mitochondrial dysfunction, alpha-synuclein) on network dysfunction and screen for novel therapeutic approaches. (PI: Patrik Verstreken, Collaborative Science Award).
Icahn School of Medicine at Mount Sinai/Continuum Health Partners Inc (Icahn School of Medicine at Mount Sinai)199,994.00742018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a computational infrastructure backend system that enables interactive exploratory analysis on enormous single-cell datasets. (PI: Uri Laserson, Human Cell Atlas Computational Tools RFA).
Washington University in St Louis150,119.00882018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a tool to facilitate single-cell transcriptome quality control, and to assign and assess cell identity in an unsupervised manner. (PI: Samantha Morris, Human Cell Atlas Computational Tools RFA).
Washington University in St Louis1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports the application of a novel, systems biology approach that leverages multi-omics in stem cells and human tissues to elucidate the mechanisms by which common genetic drivers of neuroinflammation confer resilience to neurodegenerative disease. (PI: Celeste Karch, Collaborative Science Award).
Weizmann Institute of Science160,029.00842018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the application of evolutionary theory, with the key insight that each cell needs to perform multiple tasks, to create tools to interpret the variation in molecular profiles within a cell type. (PI: Uri Alon, Human Cell Atlas Computational Tools RFA).
Wellcome Sanger Institute199,497.00762018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of open tertiary analysis platform and visualisation portal by delivering a set of prototype workflows and a proof-of-concept data portal to serve as an example of best practices for future extension and development. (PI: Kerstin Meyer, Human Cell Atlas Computational Tools RFA).
Wellcome Sanger Institute155,000.00872018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the building of an analysis pipeline that adapts phylogenetic inference methods and gene expression models in order to infer hierarchical relationships as a "Tree of Cells" which is scalable to whole organs/systems or an entire organism. (PI: Martin Hemberg, Human Cell Atlas Computational Tools RFA).
Wellcome Sanger Institute125,000.00962018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of algorithms and software implementations that will allow for fast queries of large collections of scRNA-seq datasets (PI: Martin Hemberg, Human Cell Atlas Computational Tools RFA).
Wyss Institute at Harvard University1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports the development of novel technologies to understand neurodegeneration by longitudinally profiling RNAs and proteins from neuron-derived extracellular vesicles in patient biofluids. (PI: David Walt, Collaborative Science Award).
Yale University, School of Medicine200,472.00692018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of learning data manifolds via diffusion and deep learning in order to denoise, extract structures such as clusters or trajectories, and to visualize data. (PI: Smita Krishnaswamy, Human Cell Atlas Computational Tools RFA).
J. Craig Venter Institute249,739.00492018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a scalable approach for semantically-coherent and statistically-comparable cell type definitions, using data from emerging high-throughput/high-content/high-resolution technologies. (PI: Richard Scheuermann, Human Cell Atlas Computational Tools RFA).
ZappyLab (Protocols.io)600,000.00302018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Knowledge Environments. Grant period: 2018–2019. Protocols.io is a free, up-to-date, crowdsourced protocol repository for the life sciences. This grant supports Protocols.io building an online Neurodegeneration community and expanding an online Human Cell Atlas community to increase knowledge sharing and establish best practices in methods and approaches.
Karolinska Institutet1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports identifying alterations in gene expression at a single cell level in Parkinsons Disease samples by using powerful droplet microfluidics single-nuclei RNA-seq, single molecule FISH, in situ sequencing and bioinformatics analysis and determining the function of genes with altered expression levels and their contribution to Parkinsons Disease by using novel gene editing technologies and advanced midbrain differentiation protocols for pluripotent stem cells. (PI: Ernest Arenas, Collaborative Science Award).
Lawrence Berkeley National Lab250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of spectral phenotyping as a non-destructive, label-free method to identify and capture cell types based on their spectral properties. (PI: Cynthia McMurray, Human Cell Atlas Computational Tools RFA).
Massachusetts General Hospital250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of methods and software to understand differences in how cells behave and implement these in Hail, a scalable software platform designed for biological analysis. (PI: Benjamin Neale, Human Cell Atlas Computational Tools RFA).
Massachusetts Institute of Technology (MIT)220,215.00622018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of optimal transport based algorithms to reconstruct and visualize cell trajectories, fates and ancestors, along temporal processes such as differentiation, division or tumorigenesis. (PI: Philippe Rigollet, Human Cell Atlas Computational Tools RFA).
Monash University423,449.00332018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Imaging. Grant period: 2018–2021. This grant supports a CZI Imaging Software Fellow on scikit-image to advance both the technical capabilities and the community around the base software libraries for image analysis in Python.
Mount Sinai Medical Center Inc2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports investigating the pathogenic mechanisms of mutant proteins and whether disease-mutations affect innate immune responses that could instigate or aggravate neurodegeneration. (PI: Ivan Marazzi, Early Career Award).
New York Genome Center157,402.00862018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of optimized methods, benchmarks, and best practices to integrate diverse single cell datasets and construct a unified atlas. (PI: Rahul Satija, Human Cell Atlas Computational Tools RFA).
President and Fellows of Harvard College (Harvard Medical School)2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grants supports determining whether manipulating the microbiome or engineering a bacterial toxin could treat inflammation, neuronal loss, and disease progression associated to ALS. (PI: Isaac Chiu, Early Career Award).
Princeton University219,807.00632018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a human-in-the-loop system for analysis of Human Cell Atlas data, combining statistically rigorous network algorithms with an interactive web platform for visualization, exploration, and annotation of molecular data. (PI: Benjamin Raphael, Human Cell Atlas Computational Tools RFA).
Princeton University165,000.00822018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a generative model of single cell RNA-seq data that allows normalization, imputation, and batch correction for the purpose of identifying QTLs across many individuals. (PI:Barbara Engelhardt, Human Cell Atlas Computational Tools RFA).
Princeton University165,000.00822018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the identification, correlation, and labeling of features that describe where and when a gene is expressed in single cell imaging data without manual supervision. (PI: Barbara Engelhardt, Human Cell Atlas Computational Tools RFA).
Aalto University Foundation170,296.00812018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of statistical methods that can be applied to single-cell RNA-sequencing data to quantify molecular mechanisms at the level of individual cells. (PI: Harri Lahdesmaki, Human Cell Atlas Computational Tools RFA).
Regents of the University of California at Berkeley (University of California, Berkeley)200,000.00702018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the building of computational tools that enable researchers to harness distributed computing to enable machine learning and interactive data exploration across raw single-cell data. (PI: Anthony Joseph, Human Cell Atlas Computational Tools RFA).
Regents of the University of California at San Diego (University of California, San Diego)216,753.00642018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a notebook-based analysis workspace to enable non-programming investigators to take advantage of the Human Cell Atlas resource and collect cell type expression markers for annotation of cell clusters derived from single-cell RNA-Seq data. (PI:Jill Mesirov, Human Cell Atlas Computational Tools RFA).
American Association for the Advancement of Science (American Association for the Advancement of Science)59,110.001152018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Movement for Science. Grant period: 2018–2019. SciLine is an independent, freely available service providing timely access to trustworthy, articulate experts for journalists. This grant supports a six-city bus tour in 2018 that will introduce local journalists, news editors, and television studio bookers to SciLine. This will help SciLine bring quality, vetted scientific sources to support reporting across the country.
Regents of the University of California at San Diego (University of California, San Diego)43,192.001232018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of computation methods and algorithms for integrating single-cell epigenome and transcriptome data sets to classify cell types and their biological regulation. (PI: Eran Mukamel, Human Cell Atlas Computational Tools RFA).
American Association for the Advancement of Science (American Association for the Advancement of Science)288,019.00352018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Movement for Science. Grant period: 2018–2020. This grant supports three stakeholder engagement summits that will inform the development & launch of the AAAS EPI Center, which will address important science policy issues at the forefront of the public conversation.
Regents of the University of California at San Diego (University of California, San Diego)1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant aims to determine the RNA and protein interactomes of endogenously expressed C9orf72 dipeptide repeat species and nuclear pore complex composition in ALS and FTD. (PI: Gene Yeo, Collaborative Science Award).
Regents of the University of Michigan (University of Michigan)205,788.00682018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of statistical methods and computational tools for integrating single cell RNA sequencing data with genome-wide association studies. (PI: Xiang Zhou, Human Cell Atlas Computational Tools RFA).
Regents of the University of Michigan (University of Michigan)171,000.00802018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of algorithms based on manifold alignment for integrating different types of single cell measurements. (PI: Joshua Welch, Human Cell Atlas Computational Tools RFA).
Regents of the University of Michigan (University of Michigan)75,321.001122018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a principled suite of software on two methods for marker selection and one on data imputation or matrix completion in scRNA-seq data. (PI: Anna Gilbert, Human Cell Atlas Computational Tools RFA).
Regents of the University of Michigan (University of Michigan)100,523.001082018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the analysis of single-cell RNA sequence data by using matrix factorization methods to jointly analyze such data along with bulk RNA data. (PI: Clayton Scott, Human Cell Atlas Computational Tools RFA).
Regents of the University of Michigan (University of Michigan)247,431.00552018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of computational methods to enable cost-effective multiplexing of single-cell RNA-seq experiment to population scale by harnessing cell-specific expression in addition to genetic variation. (PI: Hyun Min Kang, Human Cell Atlas Computational Tools RFA).
ASAPbio150,000.00892018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Knowledge Environments. Grant period: 2018–2021. This grant supports the advancing transparency in scientific publishing through awareness and best practices in preprinting.
Regents University of California Los Angeles (University of California, Los Angeles)2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the mapping of the integrated microbial, enteric, metabolic, immune and neuronal signaling networks that underlie microbiota-gut-brain contributions to neuropathological and neurobehavioral features common across neurodegenerative disease. (PI: Elaine Hsiao, Early Career Award).
Roswell Park Alliance Foundation85,000.001112018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the Human Cell Atlas and to enable scalable interactive statistical analysis of single-cell data. (PI:Martin Morgan, Human Cell Atlas Computational Tools RFA).
Brigham and Women's Hospital, Inc.45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the production of Bioconductor packages that combine familiar annotation for signatures and cell types with formally curated ontological vocabulary for data aggregation, statistical modeling, and visualization. (PI: Vincent Carey, Human Cell Atlas Computational Tools RFA).
Broad Institute of MIT and Harvard656,035.00292018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Imaging. Grant period: 2018–2021. This grant supports a CZI Imaging Software Fellow on the existing open-source CellProfiler codebase and contribution to collaborative open-source projects that will benefit the bioimaging software ecosystem.
Broad Institute of MIT and Harvard250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the mapping of connections between a cell's morphology and its transcriptome towards uncovering quantitative and predictive links among the various modalities. (PI: Anne Carpenter, Human Cell Atlas Computational Tools RFA).
Broad Institute of MIT and Harvard399,995.00342018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the definition of standards for sharing tertiary analysis, nucleating a small set of standardized tools, designing a registry to list standardized tools, and demonstrating the use of standardized tools. (PI: Timothy Tickle, Human Cell Atlas Computational Tools RFA).
School of Medicine - Johns Hopkins University (Johns Hopkins University)131,617.00932018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of methods for the analysis of individual genetic variation and its effects on gene expression at the single cell level, considering heterogeneity of genetic effects both within and between cell types. (PI: Alexis Battle, Human Cell Atlas Computational Tools RFA).
Broad Institute of MIT and Harvard250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the creation of the Human Cell Atlas Image Data Resource (HCA-IDR) and new software analytics capabilities by integrating existing tools into the Human Cell Atlas Data Coordination Platform for image ingestion, storage, and metadata association and by developing the *fish (Star-fish) project for generalized image analysis capabilities. (PI: Eric Banks, Human Cell Atlas Computational Tools RFA).
School of Medicine - Johns Hopkins University (Johns Hopkins University)45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI: Kasper Hansen, Human Cell Atlas Computational Tools RFA).
School of Medicine - Johns Hopkins University (Johns Hopkins University)249,275.00522018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the modification of CoGAPS to a parallel framework for efficiency and to input the underlying estimates of transcript abundance, transcriptional variance, and sparsity characteristic of single-cell RNA-sequencing data. (PI: Elana Fertig, Human Cell Atlas Computational Tools RFA).
School of Medicine - Johns Hopkins University (Johns Hopkins University)250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports developing and benchmarking rapid transfer learning methods to interrogate biological and technical basis vectors across experiments at the scale of the human cell atlas. (PI: Loyal Goff, Human Cell Atlas Computational Tools RFA).
California Institute of Technology215,530.00652018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a scalable distributed computing environment for exploratory single cell data analysis. (PI:Matt Thomson, Human Cell Atlas Computational Tools RFA).
California Institute of Technology2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2024. This grant supports understanding the mechanisms behind RNA-mediated toxicity in neurodegenerative diseases through comprehensive characterization of RNA aggregation during disease progression. (PI: Mitchell Guttman, Early Career Award).
California Institute of Technology2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2024. This grant supports understanding the role of periphery and the peripheral nervous system in propagating neurodegeneration and engineering non-invasive gene-delivery tools that specifically target non-neuronal brain cells relevant to neurodegeneration, such as immune cells and brain endothelial cells comprising the vasculature, since an impaired BBB can initiate and/or precipitate neurodegeneration. (PI: Viviana Gradinaru, Early Career Award).
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford University)158,376.00852018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a computational analysis framework, using EMT in lung cancer as an example, for generating reference maps using time series single-cell analysis to visualize EMT-tumor transient states and project new static samples on the map. (PI: Benedict Anchang, Human Cell Atlas Computational Tools RFA).
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford Univeristy)212,750.00662018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of machine learning algorithms to analyze image-based spatial transcriptomics data. (PI: James Zou, Human Cell Atlas Computational Tools RFA).
Stanford University Board of Trustees of the Leland Stanford Junior College (Stanford University)250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of easy-to-use, stable, and distributable analysis pipelines capable of providing deep insight into chromatin accessibility data sets. (PI: William J Greenleaf, Human Cell Atlas Computational Tools RFA).
Stony Brook Foundation (Stony Brook University)70,000.001132018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Movement for Science. Grant period: 2018–2019. This grant supports a wide-reaching survey, initiated by the Alda Center and led by ScienceCounts, to assess scientists' desire to engage in a range of science communication activities.
Cold Spring Harbor Laboratory1,984,012.00182018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Knowledge Environments. Grant period: 2018–2020. This grant supports the conversion of existing and new preprints on the bioRxiv service into the JATS XML format, a digital standard for scientific papers. This format will support new forms of article enhancement and presentation.
Cold Spring Harbor Laboratory2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the development of novel machine learning software to systematically identify the genetic factors and molecular mechanisms that lead to motor neuron cell death, with a particular focus on retrotransposon reactivation. (PI: Molly Gale Hammell, Early Career Award).
College of Physicians and Surgeons of Columbia University (Columbia University)220,462.00612018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the assembly of context-specific gene regulatory networks for the systematic reconstruction of single-cell states and their molecular determinants. (PI: Andrea Califano, Human Cell Atlas Computational Tools RFA).
The Board of Regents of the University of Wisconsin System (University of Wisconsin)524,871.00322018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Imaging. Grant period: 2018–2021. This grant supports a CZI Imaging Software Fellow to continue development of ImageJ/FIJI as a high performant, extensible image analysis platform and expand its interactions in a broad imaging tools ecosystem.
The Board of Regents of the University of Wisconsin System (University of Wisconsin)175,858.00782018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of novel computational methods and tools for classifying the cell type of cells using RNA-seq data and for human interaction with such data to discover associations between cell type and gene expression features. (PI: Colin Dewey, Human Cell Atlas Computational Tools RFA).
The Board of Regents of the University of Wisconsin System (University of Wisconsin)70,000.001132018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Movement for Science. Grant period: 2018–2019. Tiny Earth is a network of instructors and students focused on crowdsourcing antibiotic discovery from soil. This grant supports instructor training and community engagement to build and support scientific connections and relationships among Wisconsin higher education institutions and communities.
The Board of Trustees of the University of Illinois (University of Illinois)105,000.001032018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of new omics data quantization and lossless compression algorithms and accompanying machine learning methods that are robust to quantization errors.(PI: Olgica Milenkovic, Human Cell Atlas Computational Tools RFA).
The Board of Trustees of the University of Illinois (University of Illinois)105,000.001032018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of data compression algorithms for human cell atlas data that support the eventual end-use of the atlas, whether in-place execution of network analysis, machine learning, or for visualization. (PI: Lav Varshney, Human Cell Atlas Computational Tools RFA).
The Board of Trustees of the University of Illinois (University of Illinois)105,000.001032018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of new omics data quantization and lossless compression algorithms and accompanying machine learning methods that are robust to quantization errors. (PI: Idoia Ochoa, Human Cell Atlas Computational Tools RFA).
The Board of Trustees of the University of Illinois (University of Illinois)105,000.001032018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of new omics data quantization and lossless compression algorithms and accompanying machine learning methods that are robust to quantization errors. (PI: Mikel Hernaez, Human Cell Atlas Computational Tools RFA).
Cornell University45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI: Davide Risso, Human Cell Atlas Computational Tools RFA).
The General Hospital Corporation dba Massachusetts General Hospital (Massachusetts General Hospital)249,906.00482018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. The grant supports generating a rich multi-omic snapshot of the human hematopoietic system, developing computational strategies to detect cellular hierarchies, and recovering complex developmental trajectories for human tissues at single-cell resolution. (PI: Luca Pinello, Human Cell Atlas Computational Tools RFA).
The General Hospital Corporation dba Massachusetts General Hospital (Massachusetts General Hospital)250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the analysis of single-cell expression data of the Human Cell Atlas, by developing an efficient and scalable scRNA-seq Analysis Pipeline powered by Bayesian non-negative matrix factorization (scRNAlyzer). (PI: Gad Getz, Human Cell Atlas Computational Tools RFA).
The Jackson Laboratory250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the generation of scRNA-seq data under steady-state and immune activation conditions to test the efficacy of iteratively-adjusted surrogate variable analyses for uncovering genes and cell types associated with diverse immune responses. (PI: Duygu Ucar, Human Cell Atlas Computational Tools RFA).
Dana-Farber Cancer Institute250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports building a Cell Dynamics Portal for data visualization, exploration, and analysis with emphasis on state transitions, developmental trajectories, genetic differences, inferred dynamics, and interactions. (PI: Chris Sander, Human Cell Atlas Computational Tools RFA).
Dana-Farber Cancer Institute250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the generation of a comprehensive benchmark data set of single-cell lineage trees with endpoint cell states measurements using smFSIH and scRNA-seq for systematically comparing computational approaches and identifying standards for multi-mode integration. (PI:Sahand Hormoz, Human Cell Atlas Computational Tools RFA).
Dana-Farber Cancer Institute45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI: Rafael Irizarry, Human Cell Atlas Computational Tools RFA).
Dana-Farber Cancer Institute246,341.00562018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of an integrative computational pipeline to combine the strengths of sequencing- and imaging-based single-cell technologies. (PI: Guo-Cheng Yuan, Human Cell Atlas Computational Tools RFA).
Duke University1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports testing the functions of Parkinsons Disease genes in astrocytes as controllers of neuronal health and connectivity by applying novel molecular tools to manipulate these genes in both primary rodent and patient cell-derived astrocyte-neuron cultures and in transgenic mice, and utilize cell biological and physiological readouts of astrocyte-synapse signaling, synaptic connectivity, and neuronal health. (PI: Cagla Eroglu, Collaborative Science Award).
École Polytechnique Fédérale de Lausanne (EPFL)240,350.00582018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of the web tool ASAP (https://asap.epfl.ch/) as a reference portal for the reproducible and standardized analysis of all scRNA-seq data that will be generated as part of the HCA initiative. (PI: Bart Deplancke, Human Cell Atlas Computational Tools RFA).
The Regents of the University, Santa Cruz (University of California, Santa Cruz)750,000.00282018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports UCSC's Human Cell Atlas Data Coordination Platform and enables their ownership of data store and data browser development. (PI: Benedict Paten).
The Regents of the University, Santa Cruz (University of California, Santa Cruz)200,000.00702018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of UCSC Xena to support visualization and exploration of the Human Cell Atlas data. (PI: Jingchun Zhu, Human Cell Atlas Computational Tools RFA).
The Regents of the University, Santa Cruz (University of California, Santa Cruz)200,000.00702018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of a web-based viewer for single cell dimensionality reduction coordinates and expression matrices and integration with the UCSC Xena Browser and the UCSC Genome Browser. (PI: Max Haeussler, Human Cell Atlas Computational Tools RFA).
The Regents of the University, Santa Cruz (University of California, Santa Cruz)250,000.00362018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of standards for describing cell trajectories found in single cell RNA-Seq datasets, methods to align trajectories, and tools to search known and novel cell differentiation transitions. (PI: Josh Stuart, Human Cell Atlas Computational Tools RFA).
The Regents of University of California, Davis campus (University of California, Davis)99,084.001092018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports development of statistical models for identifying the subset of cell types and genes that are affected by perturbations in case-control single cell experiments, and to generate a benchmark dataset for validating such models. (PI: Gerald Quon, Human Cell Atlas Computational Tools RFA).
The Research Foundation for SUNY132,703.00922018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the creation and evaluation of efficient tools for quantifying gene and transcript group expression from single cell RNA-seq data, as well as a realistic data simulation tool to aid in assessment. (PI: Robert Patro, Human Cell Atlas Computational Tools RFA).
The Salk Institute For Biological Studies2,500,000.0012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2023. This grant supports the investigation of how astrocytes regulate neuronal synapse formation and function from development to aging, how dysfunctional astrocytes contribute to neurodegenerative disease, and how astrocytes may be used to stimulate synaptic repair in disease. (PI: Nicola Allen, Early Career Award).
The Trustees of Columbia University in the City of New York (Columbia University)110,000.001012018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2020. This grant supports the development of novel statistical methods enabling the fusion of multiple data types collected via different experimental technologies. (PI: Liam Paninski, Human Cell Atlas Computational Tools RFA).
European Molecular Biology Laboratory249,239.00532018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development of novel statistical approaches for integrating multiple single-cell variation datasets. (PI: Oliver Stegle, Human Cell Atlas Computational Tools RFA).
The Trustees of Columbia University in the City of New York (Columbia University)1,050,000.00192018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Neurodegeneration Challenge Network. Grant period: 2018–2021. This grant supports the generation of key reference data and a microglia experimental toolkit to identify and target different human microglial subtypes, with plans to make these tools available to the broader research community. (PI: Philip L. De Jager, Collaborative Science Award).
European Molecular Biology Laboratory249,239.00532018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI: John Marioni, Human Cell Atlas Computational Tools RFA).
The Trustees of the University of Pennsylvania (University of Pennsylvania)120,491.00982018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the building and enabling software and datasets for latent-space transformations of HCA data. (PI: Casey Greene, Human Cell Atlas Computational Tools RFA).
European Molecular Biology Laboratory45,000.001162018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports providing R / Bioconductor software as a coherent programmatic interface to the HCA and to enable scalable interactive statistical analysis of single-cell data. (PI:Wolfgang Huber, Human Cell Atlas Computational Tools RFA).
The Trustees of the University of Pennsylvania (University of Pennsylvania)150,000.00892018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the combination of crowdsourcing and machine learning to create a new platform for image processing and to develop a new conceptual framework for understanding the notion of cell type and how to manipulate it using sequencing and perturbations. (PI: Arjun Raj, Human Cell Atlas Computational Tools RFA).
European Molecular Biology Laboratory200,000.00702018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the implementation of pipelines for tertiary analyses of Human Cell Atlas data sets and develop associated, community-driven standards for the supported tools. (PI: Irene Papatheodorou, Human Cell Atlas Computational Tools RFA).
The University of Melbourne105,825.001022018Sciencehttps://chanzuckerberg.com/grants-ventures/grants/-- Program: Human Cell Atlas. Grant period: 2018–2019. This grant supports the development and implementation of computational methods as part of our existing R package mixOmics to facilitate the exploration and combined analysis of single cell assays generated across multiple studies and multiple technological platforms. (PI: Kim-Anh Lê Cao, Human Cell Atlas Computational Tools RFA).

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